Synfig Studio
Synfig Studio might not be the simplest software to master but once you get it up and running, you'll have a 2D animation software that rivals most of its contemporaries. The best part of all is that it's absolutely free.
The program was created to serve as an alternative animation tool and features plenty of features essential to a 2D artists arsenal. Development of the program was spearheaded by Robert Quattlebaum, lead software engineer and founder of the now defunct, Voria Studios.
Professionals and non-professional animators will benefit from having this program. It's a software that's packed with features to make work easier and more polished.